Open AccessThe Association Between Circulating Levels of miRNA‐181a and Pancreatic Beta Cells Dysfunction via SMAD7 in Type 1 Diabetic Children and Adolescents
Author(s) -
Nabih Enas Samir,
Andrawes Nevine Gamal
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21928
Subject(s) - microrna , autoimmunity , medicine , endocrinology , diabetes mellitus , apoptosis , beta (programming language) , immunology , biology , gene , disease , genetics , computer science , programming language
Background miRNA‐181a has been implicated in autoimmunity and apoptosis. Therefore, this study was conducted to explore its possible role in pancreatic beta‐cells dysfunction. Methods miRNA‐181a expression was evaluated by real‐time PCR in serum of 40 type 1 diabetic children and adolescents and 40 age‐ and gender‐matched healthy controls. Results miRNA‐181a expression was significantly higher in diabetic children and adolescents and it was negatively correlated to fasting C‐peptide and SMAD7 levels. Conclusion miRNA‐181a appears to play a potential role in pancreatic beta‐cells dysfunction via SMAD7.