Open AccessAssociation of Serum hs‐CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors
Author(s) -
Ebrahimi Mahmoud,
HeidariBakavoli Ali Reza,
Shoeibi Sara,
Mirhafez Seyed Reza,
Moohebati Mohsen,
Esmaily Habibollah,
Ghazavi Hamed,
Saberi Karimian Maryam,
Parizadeh Seyed Mohammad Reza,
Mohammadi Maryam,
Mohaddes Ardabili Hossein,
Ferns Gordon A.,
GhayourMobarhan Majid
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21920
Subject(s) - medicine , diabetes mellitus , waist , triglyceride , c reactive protein , endocrinology , obesity , lipid profile , metabolic syndrome , blood pressure , anthropometry , population , gastroenterology , cholesterol , inflammation , environmental health
Background Diabetes mellitus remains one of the major health problems of the 21st century and is associated with comorbidities including obesity and metabolic abnormalities. The study was conducted to evaluate serum high‐sensitivity C‐reactive protein (hs‐CRP) levels, as a marker of inflammation, in a large sample of Iranian population without a history of cardiovascular or inflammatory disease and cancer, and to relate this to fasting blood glucose (FBG) and the presence of diabetes mellitus. Methods The study consisted of 7,762 subjects divided into four groups—nonobese/nondiabetic, obese/nondiabetic, nonobese/diabetic and obese/diabetic—based on the BMI classification and their FBG. Anthropometric characteristics were measured and blood was collected for the evaluation of fasted lipid profile, FBG and serum hs‐CRP levels. Results Several clinical and biochemical characteristics were significantly different among the four groups: FBG, P < 0.001; total cholesterol (TC), P < 0.001; and triglyceride (TG), P < 0.001. The subjects with a serum hs‐CRP >3 mg/dl had higher TC ( P < 0.001), low‐density lipoprotein cholesterol (LDL‐C, P < 0.001), TG ( P < 0.001), fat percentage ( P < 0.001), and systolic and diastolic blood pressure ( P < 0.001) compared with subjects with a serum hs‐CRP <3 mg/dl. Multivariate analysis showed FBG, LDL‐C, and waist circumference (WC) associated with increased serum hs‐CRP levels ( P < 0.001). Conclusions FBG, LDL‐C, WC and gender are independently associated with serum hs‐CRP concentrations.