Open AccessCortisol, HDL‐c, VLDL‐c, and APOE Polymorphisms as Laboratorial Parameters Associated to Cognitive Impairment No Dementia (CIND) and Dementia
Author(s) -
Lara Vivian P.,
Caramelli Paulo,
Teixeira Antônio L.,
Barbosa Maira T.,
Carmona Karoline C.,
Guimarães Henrique C.,
Carvalho Maria G.,
Fernandes Ana P.,
Gomes Karina B.
Publication year - 2016
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21865
Subject(s) - dementia , apolipoprotein e , medicine , very low density lipoprotein , lipoprotein , logistic regression , lipid profile , population , psychology , endocrinology , gerontology , gastroenterology , cholesterol , disease , environmental health
Background Population aging is a global phenomenon whose main consequence is the increase of chronic degenerative diseases, including dementia. The aim of this case–control study was to evaluate the laboratorial parameters lipid profile, cortisol, and apolipoprotein E ( APOE ) gene genotype, comparing cognitively healthy controls and subjects with cognitive impairment no dementia (CIND) and dementia in a group of elderly people. Methods Three hundred and nine individuals enrolled in the Pietà Study (Brazil) were divided into three groups: control ( n = 158), CIND ( n = 92), and dementia ( n = 59). Participants were interviewed, went through examination, and had blood samples taken. Results Age and APOE showed significant differences among the groups, while sex and lipid profile did not. According to multivariate regression logistic analyses, higher cortisol levels, lower high‐density lipoprotein (HDL‐c) and very low‐density lipoprotein (VLDL‐c), presence of ε4 allele of APOE , and aging were associated with CIND and dementia. Conclusion These laboratorial parameters are risk factors associated to CIND and dementia in the elderly people and should be investigated in order to develop strategies to prevent or delay the onset of dementia in the oldest‐old populations.