Open AccessGamma Glutamyl Transferase Activity is Associated With Both Paraoxonase Activity and Aortic Stiffness in Hypertensive Patients
Author(s) -
Gözükara Mehmet Yavuz,
Börekçi Abdurrezzak,
Gür Mustafa,
Aksoy Nurten,
Şeker Taner,
Kaypaklı Onur,
Uçar Hakan,
Türkoğlu Caner,
Koç Mevlüt,
Makca İlyas,
Akyol Selahattin,
Selek Şahbettin,
Çaylı Murat
Publication year - 2015
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21785
Subject(s) - pulse wave velocity , paraoxonase , arterial stiffness , medicine , pon1 , cardiology , gastroenterology , endocrinology , blood pressure , chemistry , oxidative stress , biochemistry , genotype , gene
Background We aimed to investigate relationship between gamma glutamyl transferase (GGT) activity with paraoxonase 1 (PON1) activity and aortic stiffness (AS) parameters such as pulse wave velocity (PWV) and augmentation index (AIx). Methods Measurements were obtained from 324 patients with newly diagnosed essential hypertension (mean age: 55.0 ± 8.2 years). The patients were divided into two groups according to their median GGT values. PWV and AIx were calculated using the single‐point method via the Mobil‐O‐Graph® ARCsolver algorithm. Results PWV, Aix, and high‐sensitive C‐reactive protein (hs‐CRP) values were higher and PON1 activity values were lower in GGT high group compared with GGT low group ( P < 0.05, for all). Multiple linear regression analysis showed that GGT activity was independently associated with PWV (β = 0.496, P < 0.001) and PON1 activity (β = −0.343, P < 0.001) as well as hs‐CRP (β = 0.334, P < 0.001). Conclusion These results may support that increased GGT activity would be associated with both impaired antioxidant system and increased AS in hypertensive patients.