Open AccessSerum Cytokine Levels in Behçet's Disease
Author(s) -
Akkurt Zeynep Meltem,
Bozkurt Mehtap,
Uçmak Derya,
Yüksel Hatice,
Uçak Haydar,
Sula Bilal,
Gürsel Özkurt Zeynep,
Yildiz Mehmet,
Akdeniz Dicle,
Arica Mustafa
Publication year - 2015
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21772
Subject(s) - behcet's disease , medicine , pathogenesis , cytokine , immunology , disease , immune system , interleukin 6 , case control study , gastroenterology
Background The aim of this study is to investigate and compare the serum levels of various cytokines in patients with Behçet's Disease and healthy controls. Methods Thirty‐five patients with Behçet's disease and 29 age and sex‐matched healthy controls were included in the study. The patients were separated into groups with active and inactive disease. Serum IL‐2, IL‐6, IL‐8, IL‐10, IL‐17A, and IFN‐γ levels were determined using the enzyme‐linked immunosorbent assay method. Cytokine levels of the two patient groups and healthy controls were compared using SPSS 15.0. Results Ten patients with active disease and 25 patients with inactive disease were present. Serum IL‐8 levels of active BD patients were higher compared to inactive patients ( P = 0.048) and healthy controls ( P = 0.02). IL‐8 levels were correlated with the duration of symptoms ( r = 0.490, P = 0.003) and time passed since diagnosis ( r = 0.579, P ˂ 0.001). Conclusion Behçet's disease involves complex interactions of cells of the immune system, mainly T lymphocytes and neutrophils. Further studies on the cytokine profile in Behçet's disease will aid in elucidation of its pathogenesis.