Open AccessSerum 25‐Hydroxyvitamin D Level and Aortic Intima‐Media Thickness in Patients Without Clinical Manifestation of Atherosclerotic Cardiovascular Disease
Author(s) -
Kalkan Gülhan Yüksel,
Gür Mustafa,
Koyunsever Nermin Yıldız,
Şeker Taner,
Gözükara Mehmet Yavuz,
Uçar Hakan,
Kaypaklı Onur,
Baykan Ahmet Oytun,
Akyol Selehattin,
Türkoğlu Caner,
Elbasan Zafer,
Şahin Durmuş Yıldıray,
Çaylı Murat
Publication year - 2015
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21770
Subject(s) - medicine , vitamin d and neurology , intima media thickness , cardiology , pathogenesis , subclinical infection , tunica media , thoracic aorta , aorta , carotid arteries
Objectives Existing evidence suggests that impaired vitamin D metabolism contribute to the development of atherosclerosis. Aortic intima‐media thickness (IMT) is an earlier marker than carotid IMT of preclinical atherosclerosis. However, there is a lack of researches on direct investigation of relevance between serum 25‐hydroxyvitamin D (25(OH)D) and thoracic aortic IMT. In this study, we aimed to assess the relationship between thoracic aortic IMT and 25(OH)D. Methods We studied 117 patients (mean age: 45.5 ± 8.4 years) who underwent transesophageal echocardiography (TEE) for various indications. Serum 25(OH)D was measured using a direct competitive chemiluminescent immunoassay. The patients were divided into three groups according to the their serum 25(OH)D levels (VitD deficiency , VitD insufficient and VitD normal groups). TEE was performed in all subjects. High sensitive C‐reactive protein (hsCRP) and other biochemical markers were measured using an automated chemistry analyzer. Results Only 24.8% (29 patients) of patients had normal levels of 25(OH)D. The highest aortic IMT values were observed in VitD deficiency group compared with VitD insufficient and VitD normal groups ( P < 0.05, for all). Also aortic IMT values of VitD insufficient group were higher than VitD normal group ( P < 0.05). 25(OH)D was independently associated with hs‐CRP (β = −0.442, P < 0.001) and aortic IMT (β = −0.499, P < 0.001). Conclusions The lower 25(OH)D level was independently associated with higher aortic IMT values. Therefore, hypovitaminosis D may have a role on pathogenesis of subclinical thoracic atherosclerosis.