Open AccessRelation of the rs6923761 Gene Variant in Glucagon‐Like Peptide 1 Receptor with Weight, Cardiovascular Risk Factor, and Serum Adipokine Levels in Obese Female Subjects
Author(s) -
Luis Daniel Antonio,
Aller Rocío,
Fuente B.,
Primo D.,
Conde Rosa,
Izaola Olatz,
Sagrado Manuel Gonzalez
Publication year - 2015
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21735
Subject(s) - medicine , adipokine , endocrinology , resistin , body mass index , insulin resistance , waist , obesity , adiponectin , triglyceride , cholesterol
Background Studies of the glucagon‐like peptide 1 (GLP‐1) receptor have been directed at identifying polymorphisms in the GLP‐1 receptor gene that may be a contributing factor in the pathogenesis of diabetes mellitus and cardiovascular risk factors. Nevertheless, the role of GLP‐1 variants on body weight, cardiovascular risk factors, and adipokines remains unclear in obese patients. Objective Our aim was to analyze the effects of rs6923761 GLP‐1 receptor polymorphism on body weight, cardiovascular risk factors, and serum adipokine levels in nondiabetic obese females. Design A sample of 645 obese nondiabetic Caucasian females was enrolled in a prospective way. Basal fasting glucose, c‐reactive protein (CRP), insulin, insulin resistance (homeostasis model assessment (HOMA)), total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides concentration, and adipokines were measured. Weights, body mass index (BMI), waist circumference, fat mass by bioimpedance, and blood pressure measures were measured. Results Three hundred and twenty‐seven participants (50.7%) had the genotype GG and 318 (49.3%) study subjects had the next genotypes; GA (270 study subjects, 41.9%) or AA (48 study subjects, 7.4%) (second group). In wild group (GG genotype), BMI (1.8 ± 2.3 kg/m 2 ; P < 0.05), weight (3.1 ± 1.3 kg; P < 0.05), fat mass (2.4 ± 1.1 kg; P < 0.05), waist circumference (2.7 ± 1.9 cm; P < 0.05), triglyceride levels (10.4 ± 5.3 mg/dl; P < 0.05), interleukin 6 (IL‐6) (1.5 ± 0.9 ng/dl; P < 0.05), resistin (1.1 ± 0.3 ng/dl; P < 0.05), and leptin (30.1 ± 10.3 ng/dl; P < 0.05) levels were higher than mutant group (GA + AA). Conclusion Data from our study revealed an association with decreased metabolic and cardiovascular markers in obese females. BMI weight, fat mass, waist circumference, triglycerides, leptin, resistin, and IL‐6 serum levels were lower in subjects with A allele than non‐A allele subjects.