Open AccessAssociation Between Serum Soluble Low‐Density Lipoprotein Receptor Levels and Metabolic Factors in Healthy Japanese Individuals
Author(s) -
Shimohiro Hisashi,
Taniguchi ShinIchi,
Koda Masahiko,
Sakai Chieko,
Yamada Sadako
Publication year - 2015
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21727
Subject(s) - medicine , endocrinology , triglyceride , chemistry , lipoprotein , receptor , low density lipoprotein , body mass index , cholesterol
Background Soluble low‐density lipoprotein receptor (sLDL‐R) is formed by cleavage of the extracellular domain of low‐density lipoprotein receptor (LDL‐R). It is unclear whether serum sLDL‐R is a marker of diseases associated with triglyceride (TG) metabolism. We investigated the association between serum sLDL‐R concentrations and other biochemical parameters in healthy Japanese individuals. Methods Study subjects consisted of 102 healthy adult Japanese volunteers (42 men, 60 women) with body mass index (BMI) < 30 kg/m 2 and serum TGs, LDL cholesterol (LDL‐C), aspartate aminotransferase, alanine aminotransferase, γ‐glutamyl transpeptidase, and glucose concentrations within normal ranges. Serum sLDL‐R concentrations were determined by enzyme‐linked immunosorbent assay and their correlations with biochemical parameters were analyzed. Results Mean serum sLDL‐R concentration was 120.9 ± 39.9 ng/ml. Serum sLDL‐R levels were significantly and positively correlated with BMI ( r s = 0.252) and TG ( r s = 0.408) and LDL‐C ( r s = 0.325) concentrations. Multiple regression analysis adjusted for age, gender, and smoking showed that BMI (β = 0.274), TG (β = 0.328), and LDL‐C (β = 0.224) were factors independently correlated with sLDL‐R levels. Conclusion Serum sLDL‐R concentration may be a marker of diseases associated with TG metabolism. This is the first report to date describing the clinical relevance of sLDL‐R.