Open AccessSerum Leptin is Associated With Metabolic Syndrome in Obese Mexican Subjects
Author(s) -
GarcíaJiménez Sara,
Bernal Fernández German,
Martínez Salazar Maria Fernanda,
Monroy Noyola Antonio,
Toledano Jaimes Cairo,
Meneses Acosta Angelica,
Gonzalez Maya Leticia,
Aveleyra Ojeda Elizabeth,
Terrazas Meraz Maria A.,
MarieCatherine Boll,
SánchezAlemán Miguel A.
Publication year - 2015
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21718
Subject(s) - medicine , leptin , insulin resistance , metabolic syndrome , endocrinology , waist , abdominal obesity , dyslipidemia , obesity , overweight , insulin , body mass index , homeostatic model assessment , blood pressure
Background The metabolic syndrome (MetS) is a cluster of metabolic abnormalities including insulin resistance, dyslipidemia, high blood pressure, and abdominal adiposity. Obese patients develop leptin resistance, and an increased waist circumference (WC) due to deposition of abdominal fat. The aim of this study was to evaluate the association between circulating leptin levels and MetS among sample adult Mexican workers. Method A total of 204 workers aged 20–56 were evaluated. Anthropometric index, blood pressure, fasting plasma glucose, and lipid profile were measured by spectrophotometric methods. Fasting insulin and leptin were measured by inmunoenzimatic methods. Furthermore, homeostasis model assessment for insulin resistance (HOMA‐IR) was calculated. Results The prevalence of MetS according to the ATP‐III criteria was 33.8% and leptin concentrations were 2.5 times higher in women than men. Subjects with MetS had higher levels of leptin (26.7 ± 13.7) compared with those without MetS (20.1 ± 13.9; P <0.001). Leptin increased significantly while BMI increased as well (normal 14.0 ± 8.9, overweight 22.7 ± 11.7 and obese 31.4 ± 14.6) in addition to other variables such as WC, HDL‐C, insulin levels, and HOMA index. Each component of MetS was stratified by sex and submitted by linear regression with a 95% of accuracy. The 50% and 53% of the BMI is explained by the concentration of leptin in men and women, respectively ( P < 0.001). Conclusion This study found that leptin was associated with the MetS, especially in obesity and insulin resistance, indicating a high risk for university workers to develop hypertension, DM2, and cardiovascular disease.