Open AccessIs There a Relation Between Triglyceride Concentrations in Very Low Density Lipoprotein and the Index of Insulin Resistance in Nondiabetic Subjects?
Author(s) -
Kurosaki Yoshifumi,
Tsukushi Tomoaki,
Munekata Shinichi,
Kanoh Yuhsaku,
Moriya Tatsumi,
Nishinari Makoto,
Aoyama Naoyoshi,
Ogawa Zensuke
Publication year - 2014
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21677
Subject(s) - insulin resistance , medicine , very low density lipoprotein , endocrinology , triglyceride , insulin , diabetes mellitus , lipoprotein , quartile , cholesterol , confidence interval
Background Serum very low density lipoprotein (VLDL) levels increase during the early stages of insulin resistance; therefore, determination of VLDL levels would be useful for evaluating the progression of metabolic syndrome and diabetes mellitus. The aim of this study was to clarify the clinical utility of triglyceride in VLDL (VLDL‐TG) level, determined using a homogeneous assay kit (Shino‐test Corporation, Tokyo, Japan), as an index of insulin resistance. Methods We enrolled 74 subjects in this study (diabetic subjects, n = 42; nondiabetic subjects, n = 32). The levels of VLDL‐TG, remnant‐like lipoprotein particle cholesterol, preheparin lipoprotein lipase mass, and other biochemical markers were determined. Results VLDL‐TG levels were significantly higher in the diabetic group (1.04 ± 0.84 mmol/l vs. 0.64 ± 0.42 mmol/l, P < 0.01) than in the nondiabetic group. In the nondiabetic group, VLDL‐TG was significantly correlated with the homeostasis model assessment of insulin resistance (HOMA‐IR), the index for insulin resistance ( r = 0.513, P = 0.003). VLDL‐TG levels, but not TG levels, were higher in the highest quartile (HOMA‐IR) of the nondiabetic group. Conclusion VLDL‐TG level was a useful early marker for insulin resistance, especially in nondiabetic subjects. The homogeneous VLDL‐TG assay is a simple, low‐cost method for determining insulin resistance.