Open AccessInvestigation of Biomarker in Laryngeal Carcinomas
Author(s) -
Kanliada Deniz,
Coskunpinar Ender,
Orhan Kadir Serkan,
Oltulu Yasemin Musteri,
Celik Mehmet,
Eren Ayse,
Yaylim Ilhan,
Deger Kemal
Publication year - 2014
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21664
Subject(s) - podoplanin , pathology , thyroid cartilage , cancer , laryngeal neoplasm , medicine , metastasis , larynx , carcinoma , lymphatic system , surgery
Background The aim of the study is to determine whether there is a role of podoplanin and glutathione S‐transferases T1 (GST‐T1) expression in laryngeal squamous cell carcinoma. Methods In this study, 33 patients were enrolled and gene expression analysis was performed by qRT–PCR. The podoplanin and GST‐T1 expression patterns were analyzed to determine their correlation with clinicopathologic parameters of laryngeal cancer. Results Of all included patients, 20 had supraglottic, and 13 had glottic laryngeal cancer. Increased expression of podoplanin was found in seven (35%) supraglottic tumor tissues and seven (53.8%) glottic tumor tissues, but GST‐T1 expression was not detected. Conclusion Podoplanin expression did not show any prediction for tumor differentiation, regional metastasis, thyroid cartilage invasion, lymphatic vessel invasion, or tumor differentiation for laryngeal cancer, and also there were no significant differences in podoplanin expression between glottic and supraglottic regions, but extracapsullar extension is almost statistically significance ( P = 0.05).