Open AccessAntiadenohypophysis Autoantibodies in Patients with Nongluten‐related Gastroenteropathies
Author(s) -
Aguado Rocío,
Fernández Silvia,
Estévez Orlando A.,
Santamaría Manuel,
Ortega Consuelo
Publication year - 2014
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21644
Subject(s) - failure to thrive , autoantibody , medicine , gastroenterology , endocrinology , antibody , immunology
Aim To investigate the presence of antipituitary antibodies (APA) in the serum of patients undergoing gastroenteropathies (GEP) other than celiac disease (CD). Methods APA were analyzed in GEP patients ( n = 103), CD patients ( n = 94), idiopathic growth hormone (GH) deficiency patients ( n = 21), and 98 age‐ and sex‐matched controls. Indirect immunofluorescence was performed in cryostat sections of baboon pituitary gland. Results APA were detected in 30% of GEP patients, 38% of them showed failure to thrive. No significant differences were found when we compared thrive impairment in negative and positive APA GEP patients. Indeed, normal values of insulin‐like growth factor 1 were found in 93% of positive APA GEP patients. APA were detected in 52% of the CD patients. Ninety‐one percent of them, in contrast to GEP group, showed significant growth impairment ( P < 0.05) when compared to APA negative CD individuals. GH‐deficient non‐CD patients did not show APA. Conclusions We have shown the presence of APA in patients with nongluten‐related enteropathies. The presence of antipituitary autoantibodies in GEP patients does not seem to be associated with failure to thrive as it occurs in CD.