Open AccessBiological Variations of Some Analytes in Renal Posttransplant Patients: A Different Way to Assess Routine Parameters
Author(s) -
Ozturk Ozlem Goruroglu,
Paydas Saime,
Balal Mustafa,
Sahin Gulhan,
Karacor Esin Damla Ziyanoglu,
Ariyurek Sedefgul Yuzbasioglu,
Yaman Akgun
Publication year - 2013
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21625
Subject(s) - creatinine , uric acid , analyte , urea , albumin , chemistry , coefficient of variation , potassium , sodium , medicine , chromatography , biochemistry , organic chemistry
Background Biological variation (BV) data of analytes have been used to evaluate the significant changes in serial results (reference change value, RCV) of healthy individuals in clinical laboratories. However, BV data of healthy subjects may not be identical to the analytes of patients with ongoing clinical condition. The aim of this study was to calculate intra‐(CVw) (coefficient of variation for intra‐individual BV) and inter‐individual (CVg) BV, index of individuality, and RCV of nine serum analytes of renal posttransplant patients. Methods Six serum specimens were obtained in an interval of two months in a one‐year period from 70 transplant patients who had been stable for three years. Each time creatinine, uric acid, urea, sodium, potassium, calcium, inorganic phosphate, total protein, and albumin of these patients were analyzed with an integrated clinical chemistry/immunoassay auto‐analyzer. ANOVA tests were used to calculate the variations. Results were compared with the data of healthy subjects obtained from BV database. Results CVw of all nine analytes of the renal transplant patients were higher than the healthy subjects. RCVs of these analytes were calculated as 14.5% for creatinine, 16.5% for urea, 13.7% for urate, 12.57% for albumin, 8.26% for total protein, 3.25% for sodium, 12.81% for potassium, 5.88% for calcium, and 21.57% for inorganic phosphate. Conclusion RCV concept for predicting the clinical status in posttransplant population represents an optimization of laboratory reporting and could be a valuable tool for clinical decision.