Open AccessAssociation of Tyrosyl‐DNA Phosphodiesterase 1 Polymorphism With Tourette Syndrome in Taiwanese Patients
Author(s) -
Wu BorTsang,
Lin WeiYong,
Chou IChing,
Liu HsinPing,
Lee ChengChun,
Tsai Yuhsin,
Wu WanChen,
Tsai FuuJen
Publication year - 2013
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21606
Subject(s) - genotype , single nucleotide polymorphism , snp , xrcc1 , genetics , gene , tourette syndrome , odds ratio , polymorphism (computer science) , biology , medicine , microbiology and biotechnology , psychiatry
Background Genetic, environmental, immunological, and hormonal factors contribute to the etiology of Tourette syndrome (TS). From the genetic standpoint, TS is a heterogeneous disorder. In our previous study, we found that a single nucleotide polymorphism (SNP) of x‐ray repair cross‐complementing group 1 ( XRCC1 ), a DNA repair gene, was associated with TS. Previous studies also showed that tyrosyl‐DNA phosphodiesterase 1 (TDP1) interacts with XRCC1 to repair damaged DNA. However, the relationship between TS and SNPs of TDP1 gene is unknown. Therefore, the aim of this study was to test the hypothesis that if the TDP1 SNP, rs28365054 (c.400G>A, Ala134Thr), was associated with TS or not. Methods A case‐control study was designed to test the hypothesis. A total of 122 TS children and 106 normal children participated in the study. We used polymerase chain reaction to identify the SNP, rs28365054, of the TDP1 gene in the TS patients and the normal children. Results A polymorphism at position rs28365054 in the TDP1 gene had a significant difference ( P < 0.05) in the genotype distributions between the TS patients and the control group. The AG genotype was a risk factor for TS with an odds ratio of 2.26 for the AG versus AA genotype (95% CI 1.08–4.72). Conclusion The findings of this study suggested that variants in the TDP1 gene might play a role in TS susceptibility.