Open AccessSerum Levels of High Sensitive C Reactive Protein in Healthy Adults From Southern Brazil
Author(s) -
Delongui Francieli,
Kallaur Ana Paula,
Oliveira Sayonara Rangel,
Bonametti Ana Maria,
Grion Cintia Magalhães Carvalho,
Morimoto Helena Kaminami,
Simão Andrea Name Colado,
Magalhães Giuliana Gisele,
Reiche Edna Maria Vissoci
Publication year - 2013
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21585
Subject(s) - body mass index , c reactive protein , medicine , endocrinology , gastroenterology , inflammation
Background With the emergence of more sensitive assay techniques, it has been shown that C reactive protein ( CRP ) is present at low levels in the serum of all the clinically healthy individuals. Objective To determine the interval values of high‐sensitivity CRP (hs‐ CRP ) in healthy adults. Methods Serum hs‐ CRP level was evaluated in 176 healthy blood donors. Results The serum hs‐ CRP level ranged from <0.175 to 48.7 mg/l (median 1.2 mg/l); 127 (72.2%) individuals exhibited values ≥0.175 and <3.0 mg/l and 31 (17.6%) showed values >3.0 and ≤10.0 mg. Higher hs‐CRP level was observed among the female than male ( P = 0.0001), and among the older than the younger individuals ( P = 0.0180). Individuals with body mass index ≥25.0 kg/m 2 exhibited higher hs‐CRP level than those with normal weight (18.5–24.9 kg/m 2 ; P < 0.0005). When the participants were stratified into gender and low (≤24.9 kg/m 2 ) and high (≥24.9 kg/m 2 ) body mass index ( BMI ) groups, the gender difference in hs‐CRP levels remained (female with low BMI vs. male with low BMI , P = 0.0221; female with high BMI vs. male with high BMI , P = 0.0001). Conclusion Gender, age, and BMI influence serum hs‐CRP level in healthy individuals and these variables should be considered for the interpretation of hs‐CRP values. The results reinforce the importance in evaluating whether these differences in hs‐CRP levels could contribute to alter the cardiovascular risk criteria and clinical outcomes, and whether hs‐CRP thresholds for cardiovascular risk assessment should be adjusted for different gender and body mass index groups.