Open AccessImportance of Detecting Multidrug Resistance Proteins in Acute Leukemia Prognosis and Therapy
Author(s) -
de Moraes Ana Carolina Rabello,
Maranho Caroline Klein,
Rauber Gabriela Schneider,
SantosSilva Maria Cláudia
Publication year - 2013
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21563
Subject(s) - abcc1 , multiple drug resistance , efflux , biology , drug resistance , protein expression , medicine , cancer research , bioinformatics , genetics , gene , atp binding cassette transporter , transporter
Multidrug resistance (MDR) is a multifactorial phenomenon and the role of these proteins in generating the MDR phenotype is controversial. With this in mind, this review compiled the current data on the role of ABCB1, ABCC1, and LRP proteins in the prognosis of hematologic neoplasms and their influence on the choice of therapy. Literature showed that the detection of these proteins, mainly ABCB1, is important in the AL prognosis. However, there is controversy regarding the methodology used for their detection. In summary, the expression and activity profiles of ABCB1, ABCC1, and LRP, proteins capable of promoting the efflux of a variety of chemotherapeutic agents from the cell cytoplasm represent one of the greatest causes of failure in AL treatment. J. Clin. Lab. Anal. 27:62–71, 2013. © 2012 Wiley Periodicals, Inc.