Open AccessThe Tetrad BMI, Leptin, Leptin/Adiponectin (L/A) Ratio and CA 15‐3 are Reliable Biomarkers of Breast Cancer
Author(s) -
SantillánBenítez Jonnathan G.,
MendietaZerón Hugo,
GómezOliván Leobardo M.,
TorresJuárez Juan J.,
GonzálezBañales Juan M.,
HernándezPeña Lorena V.,
OrdóñezQuiroz Angel
Publication year - 2013
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21555
Subject(s) - leptin , medicine , adiponectin , breast cancer , odds ratio , confidence interval , body mass index , waist , endocrinology , cancer , gastroenterology , obesity , oncology , gynecology , insulin resistance
Background Several studies have reported that leptin levels, the leptin/adiponectin (L/A) ratio and carbohydrate antigen (CA) 15‐3 are especially elevated in breast cancer patients with high body mass index (BMI). The purpose of this study was to evaluate BMI, leptin, L/A ratio and CA 15‐3 all together as reliable biomarkers for breast cancer. J. Clin. Lab. Anal. 27:12–20, 2013. © 2012 Wiley Periodicals, Inc. Methods Serum levels of leptin, adiponectin and CA 15‐3, as well as anthropometric and biochemical parameters were analysed in 88 female patients who participated in a mammography study. Predictive values of BMI, leptin, L/A ratio and CA 15‐3 were determined with a 95% confidence interval. Results Women were diagnosed with either breast cancer ( n = 40) or benign breast lesions ( n = 48). Among anthropometric parameters, age ( P ≤ 0.001), weight ( P ≤ 0.05) and waist circumference ( P ≤ 0.02) were higher in patients with breast cancer than in patients without this pathology. The 75th percentile values for BMI, leptin, L/A ratio and CA 15‐3 were 29.24 kg/m 2 , 26.65 ng/ml, 2.37 and 18.45 IU, respectively. The suggested odds ratio for breast cancer patients with the values that were above the 75th percentile of the tetrad was 6.7 (0.7505–60.0665 confidence interval). Conclusion When the four variables were analysed together, a sensitivity of 83.3%, specificity of 80%, positive predictive value of 83.3% and negative predictive value of 80% were obtained. Results indicate that using the 75th percentile set points for BMI, leptin, L/A ratio and CA 15‐3 together could offer a reliable approach to determine which women are at high risk for developing breast cancer.