Open AccessMean Platelet Volume in Neonatal Sepsis
Author(s) -
Oncel Mehmet Yekta,
Ozdemir Ramazan,
Yurttutan Sadik,
Canpolat Fuat Emre,
Erdeve Omer,
Oguz Serife Suna,
Uras Nurdan,
Dilmen Ugur
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21552
Subject(s) - medicine , sepsis , mean platelet volume , white blood cell , gastroenterology , neonatal sepsis , platelet , gestational age , c reactive protein , pregnancy , inflammation , biology , genetics
Background The aim of this study was to investigate any changes in mean platelet volume (MPV) in patients with neonatal sepsis ( NS ). Methods Subjects were stratified into two groups: proven sepsis (Group 1a) and clinical sepsis (Group 1b). The control group (Group 2) consisted of healthy newborns matched for gestational age and birth weight. Results A total of 100 patients with NS (35 with proven sepsis and 65 with clinical sepsis) and 50 healthy controls were enrolled. A comparison of markers of sepsis obtained at baseline revealed white blood cell count (WBC), C‐reactive protein ( CRP ), interleukin‐6 (IL‐6), and MPV levels to be significantly higher in newborns with sepsis compared to healthy controls ( P = 0.01, <0.001, <0.001, and 0.001, respectively). Mean baseline serum levels of CRP and MPV were significantly higher in Group 1a compared to Group 1b ( P = 0.003, P = 0.007, respectively), whereas the difference between group with regards to baseline serum levels of IL‐6 and platelet count was statistically insignificant ( P = 0.14, P = 0.28, respectively). Conclusion This is the first study to demonstrate a statistically significant difference with regard to baseline MPV values between patients with sepsis (proven or clinical) and healthy controls.