Open AccessIncreased MPV Is Not a Significant Predictor for Preeclampsia During Pregnancy
Author(s) -
Altınbas Sibel,
Toğrul Cihan,
Orhan Anıl,
Yücel Munihe,
Danısman Nuri
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21542
Subject(s) - preeclampsia , medicine , mean platelet volume , proteinuria , hematocrit , obstetrics , pregnancy , eclampsia , case control study , gastroenterology , platelet , genetics , biology , kidney
Background Preeclampsia, defined as the presence of hypertension and proteinuria, is usually related with maternal and neonatal adverse effects. However, the exact predictor of preeclampsia is still lacking. Even though there are some conflicting data, mean platelet value or MPV , that is, platelet ratio with or without D oppler velocimetry was determined as highly sensitive markers for preeclampsia. We aimed to investigate the utility of MPV in prediction of preeclampsia. Methods Seventy‐four preeclamptic pregnant women (21 in mild, 53 in severe preeclampsia groups) were included in the study. To assess the difference of MPV between preeclamptic, normal pregnant, and healthy control rather than mild and severe preeclamptic pregnant women, we included in the analysis 31 healthy pregnant women and 35 healthy nonpregnant women. Results Mean age of the preeclamptic patients was 25.3 (17–38) years. Platelet levels were higher in mild preeclampsia (group 1) than severe preeclampsia (group 2), whereas alanine aminotransferase (AST), hemoglobin, and hematocrit level was higher in group 2. MPV levels were found to be similar in groups 1 and 2, MPV level increased from healthy control to preeclamptic women ( P = 0.003). MPV :platelet ratio was similar according to the severity of preeclampsia ( P = 0.123). Doppler velocimetry did not add an additional benefit to predict preeclampsia or its severity. Conclusion Our results showed that MPV level was higher in the pregnant than the control group. However, MPV did not differ both between mild and severe preeclampsia, and preeclampsia and non‐preeclamptic pregnant women. J. Clin. Lab. Anal. 26:403‐406, 2012. © 2012 Wiley Periodicals, Inc.