Open AccessExternal Evaluation of the D imension V ista 1500® Intelligent Lab System
Author(s) -
Bruneel Arnaud,
Dehoux Monique,
Barnier Anne,
Boutten Anne
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21539
Subject(s) - chemiluminescence , chromatography , spectrum analyzer , nephelometry , chemistry , biomedical engineering , computer science , medicine , telecommunications , immunology , antibody
Background D imension V ista® analyzer combines four technologies (photometry, nephelometry, V ‐ LYTE ® integrated multisensor potentiometry, and LOCI ® chemiluminescence) into one high‐throughput system. Methods We assessed analytical performance of assays routinely performed in our emergency laboratory according to the VALTEC protocol, and practicability. Results Precision was good for most parameters. Analytical domain was large and suitable for undiluted analysis in most clinical settings encountered in our hospital. Data were comparable and correlated to our routine analyzers ( R oche M odular DP ®, A bbott AXSYM ®, S iemens D imension® R x L , and BN P ro S pec®). Performance of nephelometric and LOCI modules was excellent. Functional sensitivity of high‐sensitivity C ‑reactive protein and cardiac troponin I were 0.165 mg/l and 0.03 ng/ml, respectively (coefficient of variation; CV < 10%). The influence of interfering substances (i.e., hemoglobin, bilirubin, or lipids) was moderate, and D imension V ista® specifically alerted for interference according to HIL (hemolysis, icterus, lipemia) indices. Good instrument performance and full functionality (no reagent or sample carryover in the conditions evaluated, effective sample‐volume detection, and clot detection) were confirmed. Simulated routine testing demonstrated excellent practicability, throughput, ease of use of software and security. Conclusion Performance and practicability of D imension V ista® are highly suitable for both routine and emergency use. Since no volume detection and thus no warning is available on limited sample racks, pediatric samples require special caution to the S iemens protocol to be analyzed in secured conditions. Our experience in routine practice is also discussed, i.e., the impact of daily workload, “manual” steps resulting from dilutions and pediatric samples, maintenances, flex hydration on instrument's performance on throughput and turnaround time. J. Clin. Lab. Anal. 26:384‐397, 2012. © 2012 Wiley Periodicals, Inc.