Relationship of ‐55 C/T Polymorphism of Uncoupling Protein 3 ( UCP 3) Gene with Metabolic Syndrome by ATP III Classification

Background and aims The relation of ‐55 C/T polymorphism of uncoupling protein 3 ( UCP 3) with metabolic syndrome ( MS ) has been evaluated only in one previous study with contradictory results. The aim of our study was to investigate the association of ‐55 C/T polymorphism of UCP 3 gene with MS. Design A population of 817 obese C aucasian patients was analyzed in a cross‐sectional survey. Genotype of UCP 3 gene ‐55 C/T was studied. To estimate the prevalence of MS , the definitions of the ATP III were considered. Results Five hundred and ninety‐four patients (72.7%) had the genotype ‐55CC (wild group), whereas 223 patients (27.3%) had the genotype ‐55 C/T . Genotype ‐5 TT was not detected. Prevalence of mutant UCP genotypes was similar in patients with MS (75.7% wild genotype and 24.3% mutant genotype) and without MS (69.7% wild genotype and 30.3% mutant genotype). Odds ratio of MS wild vs. mutant genotype was 1.17 CI 95%: 0.99–1.38). Total cholesterol and low density lipoprotein ( LDL ) cholesterol concentrations were lower in mutant‐type group than wild‐type group in patients with MS . No differences in other parameters were detected between genotypes in the same group of MS . Conclusion ‐55 C/T UCP polymorphism is not major risk factor for the MS . However, in mutant group of ‐55 CC UCP 3 gene in patients with MS , total cholesterol and LDL cholesterol were lower than wild‐type patients. J. Clin. Lab. Anal. 26:272‐278, 2012. © 2012 Wiley Periodicals, Inc.