Open AccessThe Clinical Significance of Serum Cystatin C in Critically Ill Newborns With Normal Serum Creatinine
Author(s) -
Cho Sun Young,
Hahn WonHo,
Lee Hee Joo,
Suh JinTae,
Lee Anbok,
Cho ByoungSoo,
Suh JinSoon
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21516
Subject(s) - cystatin c , medicine , creatinine , neonatal intensive care unit , clinical significance , critically ill , intensive care unit , intensive care , gastroenterology , pediatrics , intensive care medicine
Background The aim of this study is to evaluate the clinical significance of cystatin C ( C ys C ) in the newborns who show normal serum creatinine ( C r) and who are in an intensive care unit. Methods From July 2009 to May 2010, a total of 106 patients (53 male and 53 female newborns) in a neonatal intensive care unit at Kyung Hee Medical Center were enrolled in this study. When clinicians ordered C ys C , it was tested using HiSens Cystatin‐ C LTIA (HBi, An‐yang, Korea) on a Toshiba chemical analyzer (Toshiba, Nasushiobara, Japan). Results The range of serum C r and C ys C was from 0.1 to 0.8 mg/dL and from 1.0 to 2.3 mg/L, respectively. C ys C presented the wider amplitude of the changes in acute renal failure. Conclusion In this study, C ys C without an increased C r showed only a mild increase. However, C ys C reflected more delicate changes in newborns than the serum C r. This characteristic of C ys C could make it very appropriate for a pediatric population, especially for critically ill newborns. J. Clin. Lab. Anal. 26:267‐271, 2012. © 2012 Wiley Periodicals, Inc.