Open AccessSerum Lipid Hydroperoxide Levels and Paraoxonase Activity in Patients With Lung, Breast, and Colorectal Cancer
Author(s) -
Balci H.,
Genc H.,
Papila C.,
Can G.,
Papila B.,
Yanardag H.,
Uzun H.
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21503
Subject(s) - pon1 , arylesterase , paraoxonase , colorectal cancer , medicine , breast cancer , lung cancer , aryldialkylphosphatase , gastroenterology , cancer , endocrinology , oncology , oxidative stress , biology , biochemistry , gene , genotype
Objectives The objectives of this article are to investigate the serum lipid hydroperoxide ( LOOH ) levels and paraoxonase‐1 ( PON 1) and arylesterase ( ARE ) activity in patients with lung, breast, and colorectal cancer. Design and methods Serum PON 1 and ARE activities and LOOH levels were measured in 110 patients with cancer and same number of age‐ and sex‐matched controls. Results Serum LOOH levels were found to be increased while serum PON 1 and ARE activities were found to be decreased in patients compared to controls. PON 1 activity was found to be lower in patients with breast cancer than in patients with lung and colorectal cancer. There were positive correlations between the serum PON 1 and ARE activities in patients with colorectal cancer. Conclusion We concluded that decreased PON 1 and ARE activities and increased LOOH levels might have a connection to carcinogenesis. PON 1 activity is decreased in all patients but it does not seem to be related to metastase status except for colorectal cancer. J. Clin. Lab. Anal. 26:155‐160, 2012. © 2012 Wiley Periodicals, Inc.