Open AccessOptical and Mechanical Clot Detection Methodologies: A Comparison Study for Routine Coagulation Testing
Author(s) -
Tekkesin Nilgun,
Kılınc Cumhur
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21497
Subject(s) - partial thromboplastin time , coagulation , coagulation system , biomedical engineering , prothrombin time , coagulation testing , coefficient of variation , correlation coefficient , materials science , statistics , mathematics , engineering , medicine , surgery
Background Automated coagulation analyzers are preferred to meet increasing coagulation test volume. Two distinct technological families exist based on optical and mechanical clot detection methodologies. Which one is superior to the other is still a conflict and needs new studies. Methods We have compared prothrombin and activated partial thromboplastin results obtained with mechanical method with those obtained by photo‐optical method used routinely in our specialized laboratory. Results The instrumental results showed good precision ranging between 0.7% and 1.8% coefficient of variation. Statistical analysis demonstrated an excellent correlation between the photo‐optical and mechanical analyzers for PT ( R 2 0.97), and a PTT ( R 2 0.85). Conclusion Correlation between the two clot‐detection systems was maintained even when measuring turbid samples ( R 2 ≥ 0.97 for two tests). J. Clin. Lab. Anal. 26:125‐129, 2012. © 2012 Wiley Periodicals, Inc.