Open AccessImbalance of Circulating T ‐Lymphocyte Subpopulation in COPD and its Relationship with CAT Performance
Author(s) -
Chen Cheng,
Shen Yu,
Ni ChongJun,
Zhu YeHan,
Huang JianAn
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21490
Subject(s) - copd , medicine , lymphocyte , t lymphocyte , immunology , rank correlation , gastroenterology , lymphocyte subsets , correlation , t cell , immune system , mathematics , statistics , geometry
Chronic obstructive pulmonary disease ( COPD ) is associated with systemic effects, and T ‐cell‐mediated immunity was involved in the COPD . COPD A ssessment T est ( CAT ) could provide a valid, reliable, and standardized measure of COPD health status. The objective of this study was determination of lymphocyte subpopulation in patients with stable COPD ( n = 52) and to ascertain if a relationship existed between T ‐lymphocyte subpopulation and CAT performance. The stable COPD patients were assessed with CAT , and divided into four groups with score >30 ( n = 8), 20< score ≤30 ( n = 16), 10< score ≤20 ( n = 20), and score ≤10 ( n = 8). Spearman's rank correlation was used to determine the relationship between proportion of T lymphocyte and CAT score. We found an elevated proportion of CD 8 + cells in COPD patients of the group with score >30 compared to other groups. Proportion of CD 4 + cells was significantly lower in the groups with score >30 and 20< score ≤30 when compared to groups with 10< score ≤20 and score ≤10. The CD 4 + : CD 8 + ratio was also significantly lower in the groups with score >30 and 20< score ≤30. Of note are the correlations of proportion of CD 8 + cells and CD 4 + : CD 8 + ratio with CAT performance when score >20. No correlations existed between proportion of CD 4 + , CD 8 + cells, CD 4 + : CD 8 + ratio, and CAT performance when score ≤20. Our results show that the determinants of T ‐lymphocyte subpopulation in COPD patients were value to assess physical conditions. We considered CD 4 + and CD 8 + T lymphocytes to be a representative and stable parameter in grading of health status in COPD patients.