Open AccessBone Turnover Markers Failed to Predict the Occurrence of Osteonecrosis of the Femoral Head—A Preliminary Study
Author(s) -
Floerkemeier Thilo,
Hirsch Stefanie,
Budde Stefan,
Radtke Kerstin,
Thorey Fritz,
Windhagen Henning,
von Lewinski Gabriela
Publication year - 2012
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.21482
Subject(s) - femoral head , osteocalcin , medicine , bone remodeling , osteoarthritis , alkaline phosphatase , hormone , urology , endocrinology , surgery , pathology , chemistry , biochemistry , alternative medicine , enzyme
Background : The early detection of osteonecrosis of the femoral head (ONFH) is difficult, but important for prevention of destruction of the femoral head. The objective of this study was to determine whether the occurrence of osteonecrosis of the femoral head (ONFH) correlates with changes in bone turnover markers. Methods : In 40 patients undergoing primary total hip arthroplasty (THA), different bone turnover markers and hormones (bone specific alkaline phosphatase, osteocalcin, beta cross‐laps, 25‐hydroxy‐cholecalciferol, and parathormone) gained from blood were determined on the morning of the surgery. Twenty‐two patients needed a THA due to progressed ONFH. In 18 cases blood was gained from patients with the indication for a THA given due to advanced osteoarthritis (AO) of the hip. Results : Bone specific alkaline phosphatase, osteocalcin, beta cross‐laps, and parathormone did not show any deviation from standard values, neither for the group of osteonecrosis nor for the osteoarthritis group. 25‐Hydroxy‐cholecalciferol revealed on average decreased values without significant differences between both groups ( P < 0.05). The tested bone turnover markers and hormones failed to predict the occurrence of ONFH. Thus, the focus has to be put on different parameters to find a specific parameter that possibly predicts the risk of ostenecrosis and that is suited to follow up ONFH.