Open AccessUrinary levels of monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐8 (IL‐8), and renal injuries in patients with type 2 diabetic nephropathy
Author(s) -
Tashiro Kyouichi,
Koyanagi Ichiro,
Saitoh Akemi,
Shimizu Ayumi,
Shike Toshihide,
Ishiguro Chizuru,
Koizumi Michiko,
Funabiki Kazuhiko,
Horikoshi Satoshi,
Shirato Isao,
Tomino Yasuhiko
Publication year - 2002
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.2057
Subject(s) - medicine , diabetic nephropathy , urinary system , nephropathy , creatinine , endocrinology , diabetes mellitus , blood urea nitrogen , excretion , renal function , urine , gastroenterology , urology
We examined the correlation among the levels of urinary monocyte chemoattractant protein‐1 (MCP‐1) and interleukin‐8 (IL‐8), hyperglycemia, and renal injuries in patients with type 2 diabetic nephropathy. The levels of urinary MCP‐1, IL‐8, protein excretion, blood urea nitrogen (BUN), serum creatinine (s‐Cr), glycohemoglobin A1c (HbA1c), and fasting plasma glucose (FPG) were measured in 24 patients with type 2 diabetic nephropathy and 14 healthy adults as controls. Diabetic nephropathy was classified into three stages: stage 1 = normoalbuminuric, stage 2 = microalbuminuric, and stage 3 = macroalbuminuric. All of the patients showed normal ranges in renal function tests. Levels of urinary MCP‐1 in all patients with diabetic nephropathy were significantly higher than those in healthy adults ( P < 0.05). The levels of urinary MCP‐1 in patients with diabetic nephropathy increased gradually according to the clinical stage of this disease. In contrast, the levels of urinary IL‐8 in patients with diabetic nephropathy increased in stages 2 and 3. There was a significant correlation between the levels of urinary IL‐8 and those of HbA1c. High glucose may stimulate MCP‐1 and/or IL‐8 production and their excretion into the urine independently of the phases or pathological lesions of this disease. It appears that IL‐8 increased in the early stage of diabetic nephropathy, and MCP‐1 increased in the advanced stage of this disease. It was concluded that measurement of urinary MCP‐1 and IL‐8 may be useful for evaluating the degree of renal injuries in patients with type 2 diabetic nephropathy. J. Clin. Lab. Anal. 16:1–4, 2002. © 2002 Wiley‐Liss, Inc.