The serum profile of adipokines in naïve patients with diabetes mellitus type 2 and obesity

Background : The aim of this study was to explore the relationship of serum profile of adipokines with cardiovascular risk factors and anthropometric parameters in patients with diabetes mellitus type 2. Subjects : A population of 108 obese patients with DM2 was analyzed. A complete biochemical anthropometric and nutritional evaluation was performed. Results : In the analysis with leptin as a dependent variable, the IL‐6 and glucose levels remained in the model ( F = 6.2; P <0.05), with an increase of 5.8 (CI 95%:2.7–7.6) ng/ml with each 1 pg/ml of IL‐6 and of 5.2 (CI95%:2.5–5.8) ng/ml with each 1 mg/dl of glucose. In a second model with adiponectin as a dependent variable, the BMI remained in the model ( F = 3.77; P <0.05), with an decrease of −3.77 (CI 95%:0.53–7.1) ng/ml with each 1 point of BMI. In the third multivariate analysis with IL‐6 as a dependent variable, the glucose level remained in the model ( F = 10.1; P <0.01), with an increase of 0.09 (CI95%:0.06–0.12) pg/ml with each 1 mg/dl of glucose. In the fourth multivariate analysis with resistin as a dependent variable, the CRP remained in the model ( F = 2.51; P <0.05), with an increase of 0.28 (CI 95%:0.08–0.48) pg/ml with each 1 mg/dl of CRP. Conclusion : Serum profile of adipokines is associated with different risk factors in diabetic obese patients. J. Clin. Lab. Anal. 25:409–413, 2011. © 2011 Wiley Periodicals, Inc.