Open Accessp ‐cresylsulfate and indoxyl sulfate level at different stages of chronic kidney disease
Author(s) -
Lin ChengJui,
Chen HanHsiang,
Pan ChiFeng,
Chuang ChihKuang,
Wang TuenJen,
Sun FangJu,
Wu ChihJen
Publication year - 2011
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20456
Subject(s) - kidney disease , medicine , creatinine , renal function , hemodialysis , uremia , sulfate , gastroenterology , chemistry , endocrinology , organic chemistry
Indoxyl sulfate and p ‐cresylsulfate was associated with poor clinical outcome of uremia. We explored the relationship between the two toxins and renal function in chronic kidney disease (CKD) patients. This study enrolled 103 stable CKD patients (stage 3–5 and hemodialysis (HD) patients). Serum levels of indoxyl sulfate and p ‐cresylsulfate were measured using ultra performance liquid chromatography. General laboratory results and patient background were also checked. Patients with advanced CKD had higher serum indoxyl sulfate, p ‐cresylsulfate based on ANOVA test. There were significant correlation between indoxyl sulfate and p ‐cresylsulfate and serum creatinine after multivariate regression analysis ( B =3.59, P <0.01; B =0.93, P =0.04, respectively). In addition, there was a positive correlation between indoxyl sulfate and p ‐cresylsulfate level ( r =0.61, P <0.01). Indoxyl sulfate and p ‐cresylsulfate level increased gradually while renal function declined and reached the peak at the stage of HD. Serum indoxyl sulfate level was closely associated with p ‐cresylsulfate level in CKD patients. J. Clin. Lab. Anal. 25:191–197, 2011. © 2011 Wiley‐Liss, Inc.