Open AccessAlterations in biomarkers of endothelial function following on‐pump coronary artery revascularization
Author(s) -
Panagiotopoulos Ioannis,
Palatianos George,
Michalopoulos Argyris,
Chatzigeorgiou Antonios,
Prapas Sotirios,
Kamper Elli F.
Publication year - 2010
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20416
Subject(s) - medicine , cardiopulmonary bypass , artery , bypass grafting , cardiology , revascularization , von willebrand factor , angiotensin converting enzyme , platelet , blood pressure , myocardial infarction
Background : Cardiopulmonary bypass (CPB) has been associated with activation and injury of endothelial cells, probably responsible for the systemic inflammatory response syndrome (SIRS) taking place in these patients. Methods : We measured plasma concentrations of soluble P‐selectin (sP‐s), E‐selectin (sE‐s), tetranectin (TN), vonWillebrand factor (vWF) levels, and angiotensin‐converting enzyme (ACE) activity in 31 adult patients undergoing elective coronary artery bypass grafting, just before and up to three days after surgery, and in 25 healthy volunteers. Results : Patients showed higher plasma sP‐s and sE‐s and ACE concentrations, just before surgery, but significantly lower TN levels, compared with controls. During the first three postoperative days (PD), the concentration of each of the molecules followed a different and independent pattern, although in the third PD, the levels of sP‐s, sE‐s and ACE were higher and those of vWF and TN lower, compared with the preoperative ones. However, patients had higher sP‐s ( P =0.06), sE‐s ( P =0.07), and vWF ( P =0.005), but lower TN concentrations ( P =0.02) on the third PD compared with controls. Conclusions : CPB is characterised by pronounced changes in plasma sP‐s, sE‐s, TN, vWF levels, and ACE activity, which are associated with significant alteration in the intra‐ and early postoperative endothelial function observed in open heart surgery. J. Clin. Lab. Anal. 24:389–398, 2010. © 2010 Wiley‐Liss, Inc.