Open AccessPlatelets oxidative stress in Indian patients with ischemic heart disease
Author(s) -
Garelnabi Mahdi,
Gupta Vinod,
Mallika Venkatesan,
Bhattacharjee Jayashree
Publication year - 2010
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20363
Subject(s) - oxidative stress , lipid peroxidation , glutathione peroxidase , superoxide dismutase , antioxidant , medicine , platelet , unstable angina , myocardial infarction , platelet activation , endocrinology , chemistry , biochemistry
Background : Oxidative stress has been implicated in the development of atherosclerosis and vascular tissue injury. Both platelet activation and lipid peroxidation are known to play major role in ischemic heart disease. The purpose of this study was to investigate the status of platelets oxidative stress in Indian patients with ischemic heart disease. Methods : We measured platelets aggregation, malonyldialdehyde (MDA), plasma‐ionized Ca 2+ , and antioxidant enzymes, i.e., glutathione peroxidase and superoxide dismutase in healthy volunteers and patients with myocardial infarction, unstable and stable angina 40 subjects each. Results : Platelets aggregation, MDA, and plasma‐ionized Ca 2+ have increased significantly across the patients groups compared with controls, this increase was accompanied by an overall decrease in the antioxidant enzymes activity; except for the slight increases in the glutathione peroxidase levels among the myocardial infarction patients. Conclusions : The current results suggest that platelet lipid peroxidation as marked by increased MDA level is augmented in ischemic heart diseases. The increased oxidative stress seen in these patients was accompanied by platelet activation and impaired antioxidant enzymes activity. J. Clin. Lab. Anal. 24:49–54, 2010. © 2010 Wiley‐Liss, Inc.