Open AccessAssociation of β‐1 and β‐2 adrenergic receptor gene polymorphisms with myocardial infarction
Author(s) -
Yilmaz Akin,
Kaya Mehmet G.,
Merdanoglu Ulgen,
Ergun Mehmet A.,
Cengel Atiye,
Menevse Sevda
Publication year - 2009
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20327
Subject(s) - allele , haplotype , medicine , myocardial infarction , heterozygote advantage , population , adrenergic receptor , endocrinology , turkish population , adrenergic , polymorphism (computer science) , receptor , genotype , biology , genetics , gene , environmental health
Both β 1 ‐ and β2‐adrenergic receptors (β 1 ‐ and β 2 ‐AR) have important roles in heart function mainly in response to catecholamines. Some specific polymorphisms in the β 1 ‐ and β 2 ‐AR genes, named ADRB1 and ADRB2, respectively, have been implicated in several cardiovascular and noncardiovascular phenotypes. In this study, we aimed to investigate the possible relationship between Ser49Gly and Arg389Gly polymorphisms of the ADRB1 and Arg16Gly and Gln27Glu polymorphisms of the ADRB2 gene with ST elevation myocardial infarction (MI) in a Turkish population. One hundred patients with ST elevation MI and 100 healthy control subjects were genotyped using the PCR‐RFLP method. Although the Arg389 allele of the ADRB1 gene was associated with an elevated risk of MI, the Glu27 allele of the ADRB2 gene was associated with a decreased risk of MI. Carriers of the ADRB1 Arg389 allele (heterozygotes+homozygotes) had an approximately 3.5‐fold increased risk for MI than Gly389 homozygotes (OR=3.59, 95% CI=0.96–13.47, P =0.045). For the ADRB2 Gln27Glu polymorphism, subjects having one or two copies of the Glu27 allele showed a decreased risk of MI compared with Gln27 homozygote subjects (OR=0.48, 95% CI=0.24–0.94, P =0.03). Haplotype analysis of these polymorphisms showed no significant differences between groups. These results suggest that the Arg389Gly and Gln27Glu polymorphisms may be associated with an altered risk of MI in this Turkish population. J. Clin. Lab. Anal. 23:237–243, 2009. © 2009 Wiley‐Liss, Inc.