Open AccessDetermining urinary trace elements (Cu, Zn, Pb, As, and Se) in patients with bladder cancer
Author(s) -
Lin ChangNi,
Wang LaiHao,
Shen KunHung
Publication year - 2009
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20318
Subject(s) - selenium , zinc , urinary system , urine , bladder cancer , atomic absorption spectroscopy , arsenic , urinary bladder cancer , graphite furnace atomic absorption , chemistry , cancer , trace element , copper , urinary bladder , medicine , urology , chromatography , physics , organic chemistry , quantum mechanics , detection limit
Objectives : Trace elements are essential components of biological structures, but they can be toxic at concentrations beyond those necessary for their biological functions. Methods : A study group of 30 patients with bladder cancer and a control group of 30 healthy volunteers were measured for trace elements using a graphite furnace atomic absorption spectrophotometer. Results : Urinary zinc and selenium levels in patients were significantly ( P <0.05) higherthan those in controls, but urinary copper, arsenic, and lead were not significantly different. Conclusion : This case–control study suggests that zinc and selenium concentrations are associated with the proliferation of bladder cancer cells because zinc and selenium are excreted in the urine of bladder cancer patients. J. Clin. Lab. Anal. 23:192–195, 2009. © 2009 Wiley‐Liss, Inc.