Open AccessSerum lipid profile, oxidative status, and paraoxonase 1 activity in hyperemesis gravidarum
Author(s) -
Aksoy Hulya,
Aksoy Ayse Nur,
Ozkan Asuman,
Polat Harun
Publication year - 2009
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20298
Subject(s) - arylesterase , pon1 , paraoxonase , malondialdehyde , medicine , endocrinology , oxidative stress , triglyceride , chemistry , lipid profile , high density lipoprotein , antioxidant , apolipoprotein b , cholesterol , low density lipoprotein , lipoprotein , biochemistry , genotype , gene
The aim of this study was to investigate lipid profile, paraoxonase 1 (PON1) activity, and oxidative stress status in the serum of hyperemesis gravidarum (HG) patients. Thirty‐six HG cases and 36 normal pregnants were included in the study. Serum total cholesterol (TC), triglyceride (TG), high‐density lipoprotein cholesterol (HDL‐C), low‐density lipoprotein cholesterol (LDL‐C), apoproteins A1 (apo A1) and B (apo B), malondialdehyde (MDA), and total antioxidant activity (TAO) values and PON1 and arylesterase activities were determined. Although serum TC, TG, LDL‐C, and apo B levels were not different among; the groups ( P >0.05), HDL‐C ( P =0.01) and apo A1 ( P =0.007) levels were lower in HG patients than in normal pregnants. HG group had significantly lower serum PON1 ( P =0.03) and arylesterase activities ( P =0.03) compared with the control group. Additionally, mean TAO values were lower ( P =0.01) and MDA levels were higher ( P =0.02) in HG group than in the healthy pregnants. A significant negative correlation between PON1 and MDA was found in HG group ( r =−0.33, P <0.05). The findings of this study have revealed that HG may be one of the conditions in which oxidant and antioxidant balance is impaired. J. Clin. Lab. Anal. 23:105–109, 2009. © 2009 Wiley‐Liss, Inc.