Open AccessViral loads of cerebrospinal fluid in infants with enterovirus meningitis
Author(s) -
Kawashima Hisashi,
Ioi Hiroaki,
Ishii Chiako,
Hasegawa Yuka,
Amaha Masahiro,
Kashiwagi Yasuyo,
Takekuma Kouji,
Hoshika Akinori,
Watanabe Yasuo
Publication year - 2008
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20244
Subject(s) - viral meningitis , cerebrospinal fluid , pleocytosis , meningitis , enterovirus , viral load , radical , medicine , enterovirus 71 , virology , immunology , virus , pediatrics , chemistry , bacterial meningitis , organic chemistry
For a better understanding of the role of the viral load, free radicals, and cytokines in viral meningitis, we surveyed cerebrospinal fluid (CSF) obtained from patients below 1 year of age who showed positive for enterovirus. In their first examinations interleukin (IL)‐6 and free radicals increased whereas pleocytosis was rarely observed. IL‐6 decreased within the short period. Viral loads and free radicals increased simultaneously. IL‐6 and free radicals of CSF are helpful for diagnosis and treatment of viral meningitis at an early stage. J. Clin. Lab. Anal. 22:216–219, 2008. © 2008 Wiley‐Liss, Inc.