Open AccessClinical role of recurrently elevated macro creatine kinase type 1
Author(s) -
Hsiao JuFeng,
Ning HsiaoChen,
Gu PoWen,
Lin WeiYee,
Chu PaoHsien
Publication year - 2008
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20239
Subject(s) - creatine kinase , medicine , gastroenterology , sepsis , isozyme , clinical significance , creatinine , pathology , biology , enzyme , biochemistry
The typical creatine kinase (CK) isoenzymes include CK‐BB, CK‐MB, and CK‐MM. Macro CK type 1, one of the atypical CK enzymes, has been identified in human serum, but the clinical significance still remains uncertain. In our laboratory, 105 patients who expressed serum macro CK isoenzyme type 1 were identified from March 2004 to March 2007. We found that macro CK type 1 recurred after at least one month in 16 patients. Clinical diagnoses were myopathy in 14 patients, sepsis in one, and acute coronary syndrome in one. The averages of serum total CK and macro CK type 1 were 9,132 and 1,925 (U/L), respectively. The linear regression analysis between recurrent macro CK type 1 and total CK revealed a good correlation ( y =3.5054 x +2381.3, R 2 =0.7822, P <0.001). Three patients had critical illness, including one respiratory failure and two mortalities. Good linear correlation is documented between total CK and recurrent macro CK type 1. In conclusion, the macro CK type I isoenzyme recurred primarily in patients with myopathy. J. Clin. Lab. Anal. 22:186–191, 2008. © 2008 Wiley‐Liss, Inc.