Determination of terephthalic acid isopropylamide in urine with a liquid chromatography/mass spectrometry (LC/MS) method | Zendy

Baumann F. | Zendy; MauzKörholz C. | Zendy; Clauß D. | Zendy; Borrmann S. | Zendy; Giannis A. | Zendy; Merkel N. | Zendy; Körholz D. | Zendy; Preiss R. | Zendy

Open Access

Determination of terephthalic acid isopropylamide in urine with a liquid chromatography/mass spectrometry (LC/MS) method

Author(s) -

Baumann F.,

MauzKörholz C.,

Clauß D.,

Borrmann S.,

Giannis A.,

Merkel N.,

Körholz D.,

Preiss R.

Publication year - 2008

Publication title -

journal of clinical laboratory analysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.536

H-Index - 50

eISSN - 1098-2825

pISSN - 0887-8013

DOI - 10.1002/jcla.20213

Subject(s) - chromatography , chemistry , terephthalic acid , mass spectrometry , urine , liquid chromatography–mass spectrometry , detection limit , metabolite , solid phase extraction , extraction (chemistry) , selected reaction monitoring , gas chromatography–mass spectrometry , tandem mass spectrometry , organic chemistry , biochemistry , polyester

A sensitive and simple liquid chromatography/mass spectrometry (LC/MS) method was developed for the determination of terephthalic acid isopropylamide, the final metabolite of procarbazine in human urine. A solid‐phase extraction with C 18 cartridges was used followed by LC/MS with a single mass spectrometer (SSQ 7000 from Finnigan). Terephthalic acid isobutylamide was the internal standard. The quantification limit was 30 ng/mL in urine (6 × noise). This assay was applied for drug monitoring of terephthalic acid isopropylamide in urine after oral administration of procarbazine in children and adolescents with Hodgkin lymphomas. J. Clin. Lab. Anal. 22:21–28, 2008. © 2008 Wiley‐Liss, Inc.

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