Open AccessAge‐related changes in bone turnover markers and ovarian hormones in premenopausal and postmenopausal Indian women
Author(s) -
Desai Meena P.,
Bhanuprakash K.V.,
Ikram Khatkhatay M.,
Donde Uday M.
Publication year - 2007
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.20166
Subject(s) - postmenopausal women , bone remodeling , hormone , medicine , physiology , menopause , endocrinology , gynecology
Abstract This study characterizes age‐related changes in bone turnover markers in relation to ovarian hormones. The data (N = 236) were divided into 5‐year age bands and three groups: premenopausal (Group I, N = 139), perimenopausal (Group II, N = 30), and postmenopausal (Group III, N = 67). Age‐related increases in mean parathyroid hormone (PTH), osteocalcin (OC), and collagen telopeptide (CTx) levels were observed. Women in Group II (N = 37) with osteopenia had lower levels of E 1 G ( P <0.001) with normal FSH levels as compared to 50 women in the same group with normal bone mineral density (BMD). Their mean OC levels were reduced ( P <0.05) and CTx levels were significantly elevated ( P <0.01). The mean E 1 G levels were significantly lower ( P <0.001) and mean CTx levels were significantly higher ( P <0.001) in 30 perimenopausal women (Group II) compared to premenopausal women. In 28 postmenopausal women (group III) the mean BMD levels and E1G were significantly lower ( P <0.001) with elevated FSH levels ( P <0.001). Increased CTx levels ( P <0.0001) reflected a higher rate of bone resorption. These observations suggest that perimenopausal women with low E 1 G, elevated FSH should be screened for osteoporosis, and it may be valid to combine simultaneous measurements of bone turnover markers with ovarian hormones when screening women at risk for osteoporosis. J. Clin. Lab. Anal. 21:55–60, 2007. © 2007 Wileyhyphen;Liss, Inc.