Open AccessMyelin‐ and microbe‐specific antibodies in guillain‐barré syndrome
Author(s) -
Terryberry Jeff,
Sutjita Made,
Shoenfeld Yehuda,
Gilburd Boris,
Tanne David,
Lorber Margalit,
Alosachie Iyad,
Barka Noori,
Lin HunChi,
Youinou Pierre,
Peter James B.
Publication year - 1995
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860090506
Subject(s) - autoantibody , antibody , immunology , guillain barre syndrome , molecular mimicry , virology , cardiolipin , medicine , polyclonal antibodies , autoimmunity , biology , phospholipid , membrane , genetics
We surveyed the frequency of reported infections and target autoantigens in 56 Guillain Barré syndrome (GBS) patients by detecting antibodies to myelin and microbes. Sulfatide (43%), cardiolipin (48%), GD 1a (15%), SGPG (11%), and GM 3 (11%) antibodies were the most frequently detected heterogenous autoantibodies. A wide spectrum of antimicrobial IgG and IgM antibodies were also detected; mumps‐specific IgG (66%), adenovirus‐specific IgG (52%), varicella‐zoster virus‐specific IgG (46%), and S. pneumoniae serotype 7‐specific IgG (45%) were the most prevalent. Our results indicate that polyclonal expansion of physiologic and pathologic antibodies and/or molecular mimicry likely occurs following infection and is related to other autoimmune factors in the etiology of GBS. Although no single definitive myelin‐specific autoantibody was identified, our results suggest a unique pattern of reactivity against autoantigens.