Open AccessDouble immunochemical screening test (hemoglobin and albumin) for the detection of occult intestinal bleeding
Author(s) -
Otto Szabolcs,
Nemeth MÁRia
Publication year - 1993
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860070602
Subject(s) - hemoglobin , occult , albumin , fecal occult blood , gastroenterology , screening test , medicine , chemistry , pathology , colonoscopy , colorectal cancer , cancer , alternative medicine , family medicine
The authors have developed a combined electrophoretic‐immunoprecipitation technique suitable for the simultaneous demonstration of two blood proteins, i.e., hemoglobin and albumin, in the feces. The analytical sensitivity of the method is 2 μg hemoglobin and albumin/ml. The technique is simple, inexpensive, and suitable for the reliable demonstration of occult intestinal bleeding for either inpatients or mass screening. This technique is an aid not only to the fact that bleeding can be detected, but to its intensity, as well. This new technique improves the diagnostic accuracy of early detection of carcinomas and polyps, presumably without raising significantly the number of “false‐positive” reactions. © 1993 Wiley‐Liss, Inc.