Effect of anticardiolipin antibody in patients with recurrent fetal loss on thrombomodulin‐dependent protein C activation | Zendy

Toyoshima Kiwamu | Zendy; Makino Tsunehisa | Zendy; Ozawa Nobuaki | Zendy; Umeuchi Masakatsu | Zendy; Nozawa Shiro | Zendy

Open Access

Effect of anticardiolipin antibody in patients with recurrent fetal loss on thrombomodulin‐dependent protein C activation

Author(s) -

Toyoshima Kiwamu,

Makino Tsunehisa,

Ozawa Nobuaki,

Umeuchi Masakatsu,

Nozawa Shiro

Publication year - 1993

Publication title -

journal of clinical laboratory analysis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.536

H-Index - 50

eISSN - 1098-2825

pISSN - 0887-8013

DOI - 10.1002/jcla.1860070110

Subject(s) - thrombomodulin , anticardiolipin antibodies , protein c , antibody , fetus , antiphospholipid syndrome , titer , medicine , in vivo , immunology , thrombin , endocrinology , pregnancy , biology , platelet , genetics , microbiology and biotechnology

In order to approach an understanding of the mechanisms of fetal death in patients with antiphospholipid syndrome we investigated the association between protein C activity and anticardiolipin antibody. Protein C activity in vivo was decreased in some patients with recurrent fetal loss and a high ACA titer. This study suggests that anticardiolipin antibody in patients with recurrent fetal loss may inhibit activation of protein C by thrombomodulin. © 1993 Wiley‐Liss, Inc.

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