Open AccessEffect of anticardiolipin antibody in patients with recurrent fetal loss on thrombomodulin‐dependent protein C activation
Author(s) -
Toyoshima Kiwamu,
Makino Tsunehisa,
Ozawa Nobuaki,
Umeuchi Masakatsu,
Nozawa Shiro
Publication year - 1993
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860070110
Subject(s) - thrombomodulin , anticardiolipin antibodies , protein c , antibody , fetus , antiphospholipid syndrome , titer , medicine , in vivo , immunology , thrombin , endocrinology , pregnancy , biology , platelet , genetics , microbiology and biotechnology
In order to approach an understanding of the mechanisms of fetal death in patients with antiphospholipid syndrome we investigated the association between protein C activity and anticardiolipin antibody. Protein C activity in vivo was decreased in some patients with recurrent fetal loss and a high ACA titer. This study suggests that anticardiolipin antibody in patients with recurrent fetal loss may inhibit activation of protein C by thrombomodulin. © 1993 Wiley‐Liss, Inc.