Open AccessImpaired cytokine production in whole blood cell cultures from patients with colorectal carcinomas as compared to benign colorectal tumors and controls
Author(s) -
ElsässerBeile U.,
von Kleist S.,
Fischer R.,
Mönting J. Schulte
Publication year - 1992
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860060510
Subject(s) - cytokine , medicine , immune system , colorectal cancer , interleukin 10 , gastroenterology , immunology , cancer research , oncology , cancer
Cytokine production was investigated in whole blood cell cultures from 74 patients with colorectal carcinomas, 20 patients with benign colorectal tumors, and 314 healthy controls. In the 4 day post induction supernatants the levels of IFN‐gamma, IL‐1‐alpha, IL‐2, and TNF‐alpha were mesured by a sensitive immunoassay. In the blood cell cultures of the patients with colorectal carcinomas significantly lower values of IFN‐gamma (P ⩽.001), IL‐1‐alpha (P⩽.001), and IL‐2(p⩽.01) were found as compared to the patients with bening tumors and the controls, although total and differential leukocyte counts were similar in all three groups. A liner correlation between the levels of IFN gamma and IL‐1‐alpha and the tumor stages could be shown. Our results suggest that a growing tumor burden may induce increasing immunological deficiencies as reflected by a decreasing cytokine production of the immune cells. © 1992 Wiley‐Liss, Inc. © 1992 Wiley‐Liss, Inc.