Open AccessElevation of platelet‐associated IgG in aplastic anemia
Author(s) -
Kawaguchi Ryuji,
Haruna Shoji,
Hikiji Kazumasa,
Higashi Yasuko,
Tsukada Yutaka
Publication year - 1992
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860060306
Subject(s) - aplastic anemia , platelet , medicine , autoimmune hemolytic anemia , immunology , anemia , thrombocytopenic purpura , gastroenterology , bone marrow
We determined platelet‐associated IgG (PAIgG) levels in patients with aplastic anemia, idiopathic thrombocytopenic purpura (ITP), iron deficiency anemia, and systemic lupus erythematosus (SLE), as well as in normal healthy adults as a control group. To determine PAIgG levels, we used a competitive micro enzyme‐linked immunosorbent assay, which had excellent reproducibility, recovery, and dilution. We confirmed its reliability by comparing it to the immunoradiometric assay. Both the aplastic anemia group (n = 27, mean ± SD = 218.6 ± 244.6ng/10 7 platelets) and the ITP group (n = 82, mean ± SD = 212.5 ± 327.8 ng/10 7 platelets) had higher PAIgG levels than the SLE group (n = 4, mean ± SD = 38.4 ± 22.4 ng/10 7 platelets), iron deficiency anemia group (n = 10, mean ± SD = 16.1 ± 3.6ng/10 7 platelets), and normal control group (n) = 69, mean ± SD = 16.1 ± 3.6ng/10 7 platelets. The higher platelet associated IgG levels in aplastic anemia suggest that autoimmune mechanisms are involved. © 1992 Wiley‐Liss, Inc.