Open AccessNeopterin and β 2 ‐microglobulin and the assessment of intra‐blood‐brain‐barrier synthesis of hiv‐specific and total igg
Author(s) -
Peter James B.,
McKeown Karen L.,
Barka Noori E.,
Tourtellotte Wallace W.,
Singer Elyse J.,
Syndulko Karl
Publication year - 1991
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860050504
Subject(s) - neopterin , beta 2 microglobulin , nephelometry , medicine , asymptomatic , immunology , antibody , cerebrospinal fluid
In HIV‐seropositive patients, we evaluated the clinical utility of measuring combinations of serum and CSF levels of neopterin and β 2 ‐microglobulin (β 2 ‐M) (by RIA), as well as the intra‐blood‐brain‐barrier (IBBB) IgG Synthesis rate, IgG index, and HIV antibody index (by rate nephelometry, EIA, and formulae) for the assessment of HIV infection of the CNS. We studied paired sera and CSF from 31 HIV‐seropositive patients: asymptomatic (16), ARC (12), and AIDS (3). A normal serum neopterin level predicts normal levels of serum β 2 ‐M, CSF neopterin, or CSF β 2 ‐M in 90%, 100%, and 100%, respectively, of our patients. An elevated serum neopterin level predicts an elevated level of serum β 2 ‐M or CSF neopterin in 81% and 62%, respectively, of cases. The HIV antibody index and IBBB IgG synthesis rate or IgG index must be determined separately because they do not predict each other and are not predicted by levels of neopterin or β 2 ‐M.