Open AccessImportance of detection of ss‐a/ro autoantibody in screening immunofluorescence tests for autoantibodies to nuclear antigens
Author(s) -
Bylund David J.,
Nakamura Robert M.
Publication year - 1991
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860050311
Subject(s) - autoantibody , immunofluorescence , extractable nuclear antigens , antigen , immunology , medicine , indirect immunofluorescence , lupus erythematosus , anti nuclear antibody , antibody
SS‐A/Ro autoantibodies are related to Sjögren's syndrome and to several clinical subsets of lupus erythematosus. The most widely used laboratory procedure for ANA screening is the indirect immunofluorescence test (IF‐ANA); the laboratory detection of anti‐SS‐A/Ro requires implementation and adherence to several technical and quality assurance recommendations. Using appropriate substrate cells containing the SS‐A/Ro antigen, many so‐called “ANA‐negative” lupus erythematosus patients will demonstrate a positive IF‐ANA.