Open AccessProstaglandin production in chronic progressive multiple sclerosis
Author(s) -
Aberg Judith A.,
Demers Laurence M.,
Romano Paula J.,
Tenser Richard B.
Publication year - 1990
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860040403
Subject(s) - exacerbation , multiple sclerosis , thromboxane b2 , prostaglandin , immune system , thromboxane , peripheral , prostaglandin e , medicine , in vitro , immunology , thromboxane a2 , prostaglandin e2 , endocrinology , chemistry , platelet , biochemistry
Peripheral blood monocytes have been implicated in the immune reactions that accompany demyelination in patients with multiple sclerosis (MS). We measured prostaglandin E 2 (PGE 2 ) and thromboxane B 2 (TxB 2 ) release from peripheral monocytes exposed in vitro to complement. Our studies suggest that there is a significantly higher production of PGE 2 in monocytes from patients with chronic progressive MS than in those with exacerbation or remitting MS and healthy controls. No significant differences in TxB 2 release were noted between the three groups.