Open AccessAssay methods for cyclosporine monitoring following liver transplantation
Author(s) -
Haven Mary C.,
Sobeski Linda M.,
Earl Robert A.,
Markin Rodney S.
Publication year - 1990
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860040214
Subject(s) - therapeutic drug monitoring , liver transplantation , immunoassay , metabolite , transplantation , medicine , pharmacology , drug , intensive care medicine , immunology , antibody
This article reviews therapeutic drug monitoring for cyclosporine in liver transplantation. Brief descriptions of various immunoassay methods include sample matrix selection, assay reagents, and metabolite cross‐reactivity information. Multiple comparisons of the various methods are outlined. Examples of the method‐dependent relationship between clinical events and changes in cyclosporine concentration are presented. Other potential predictors of liver allograft function are listed.