Open AccessHumoral and cellular immune responses to salmonella typhi in patients with typhoid fever
Author(s) -
Mastroianni C. M.,
Jirillo E.,
De Simone C.,
Grassi P. P.,
Maffione A. B.,
Catino A. M.,
Vullo V.,
Misefari A.,
Delia S.
Publication year - 1989
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860030310
Subject(s) - typhoid fever , salmonella typhi , immunology , immune system , antibody , cellular immunity , immunity , humoral immunity , typhoid vaccine , titer , antibody titer , medicine , peripheral blood mononuclear cell , biology , virology , in vitro , gene , biochemistry , escherichia coli
Humoral and cellular immune responses to Salmonella typhi have been studied in nine children with typhoid fever. By using dot immunobinding assay, anti‐O‐polysaccharide chain and antilipid A antibody titers have been evaluated during the course of the disease. Anti‐O‐polysaccharide chain antibody titers are lower at the first week and increase up to the third week of the infection. On the other hand, antilipid A antibody levels, which are already higher at the beginning of the disease, progressively augment during the following weeks. Concerning cellular immunity to S. typhi , antibacterial activity mediated by typhoid peripheral mononuclear cells has been determined. Results show this function to be depressed in the initial phase of typhoid, increasing with the time. Together, these data bring new insight on immunity in typhoid patients.