Open AccessSerum pregnancy‐associated α 2 ‐glycoprotein levels in the evolution of Hepatitis B virus infection
Author(s) -
Zarzur Jorge A.,
Aldao Mario,
Sileoni Santos,
Vides Miguel A.
Publication year - 1989
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860030202
Subject(s) - hbsag , hepatitis b virus , medicine , asymptomatic , alpha (finance) , pregnancy , immunology , glycoprotein , virus , gastroenterology , hepatitis b , virology , biology , surgery , microbiology and biotechnology , genetics , construct validity , patient satisfaction
Serum pregnancy‐associated α 2 ‐glyco‐protein (α 2 ‐PAG) levels were evaluated in a follow‐up study of patients with hepatitis B virus (HBV) infection and compared with biochemical and virological parameters. In a study of 25 patients with acute hepatitis, an association was found between high a 2 ‐PAG values, ALT levels, and HB s Ag in 20 patients (80%) ( P <0.05), 18 recovered completely, and 2 had a protracted course. In five patients serum a 2 ‐PAG levels were similar to those in the control group. On the other hand, eight (100%) chronic persistent HEW patients showed high levels of α 2 ‐PAG (P < 0.05) during the study period, and these levels correlated well with inflammatory activity and failure of HB s Ag elimination. There were no significant differences in α 2 ‐PAG values between asymptomatic HB s Ag carriers and controls. Serial analysis of α 2 ‐PAG, in correlation with viral markers, biochemical parameters, and histological data, would contribute to the ability to predict the final outcome of HBV infection.