Open AccessSera from AIDS patients contain multiple factors that suppress in vitro proliferation of lymphoid cells
Author(s) -
Hennig Anne K.,
John Patricia A.,
Blair Donald C.,
Tomar Russell H.
Publication year - 1988
Publication title -
journal of clinical laboratory analysis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 50
eISSN - 1098-2825
pISSN - 0887-8013
DOI - 10.1002/jcla.1860020407
Subject(s) - peripheral blood mononuclear cell , in vitro , immunology , peripheral blood , cell growth , mitogen activated protein kinase , medicine , biology , genetics
In previous studies we found that sera from patients with AIDS and AIDS‐related disorders inhibit mitogen‐stimulated proliferation of peripheral blood mononuclear cells from healthy donors. We have extended these studies to examine the effect of AIDS sera on proliferation of various IL‐ 2independent, well‐characterized T4‐positive and T4‐negative continuous human lymphoid cell lines. The results suggest that AIDS serum inhibition results from several mechanisms, one involving the induction of prostaglandin E2.